Genome-wide tag scanner for nuclease off-sites
Background:
Based on the
Tagger software, this application is intended to search genomes for specific target sites and off-target sites, such as for pairs of zinc finger proteins (ZFPs), zinc finger nucleases (ZFNs) and modified homing endonucleases. This can either define a zinc finger nucleases (hetero-dimer) or allow for homo-dimers depending on the status of the checkbox in the input form.
Reference:
Provisional PDF:
BMC Bioinformatics
ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites
Thomas J Cradick, Giovanna Ambrosini, Christian Iseli, Philipp Bucher, Anton P McCaffrey
BMC Bioinformatics 2011, 12:152 (13 May 2011)